Table 1. Clinical characteristics according to MC4R genotypes (functional MC4R mutations, MC4R polymorphisms and the variant rs17782313 downstream MC4R).
| Functional MC4R mutations | Variant rs17782313 | MC4R polymorphisms: Val130Ile, Ile251Leu | MC4R polymorphism: A-178C | ||||||
| Carriers | Non carriers | Carriers | Non carriers | Carriers | Non carriers | Carriers | Non carriers | ||
| Number, n | 9 | 18 | 7 | 14 | 10 | 20 | 22 | 44 | |
| Age, years | 36.2 (13.3) | 34.2 (8.4) | 45.4 (9.2) | 46.1(9.9) | 39.2 (12.2) | 42.4 (9.1) | 46.1 (7.9)* | 43.3 (9.1)* | |
| % Female | 100 | 100 | 71.4 | 71.4 | 80 | 80 | 86.4 | 86.4 | |
| Surgery Type | Gastric banding | 3 | 6 | 0 | 0 | 2 | 4 | 0 | 0 |
| Bypass | 6 | 12 | 7 | 14 | 8 | 16 | 22 | 44 | |
| Weight, kg | Baseline | 139.2 (14.3) | 139.8 (12.1) | 142.0 (23.9) | 133.4 (15.5) | 121.6 (18.2) | 125.1 (16.0) | 126.4 (16.4) | 124.3 (13.9) |
| BMI, kg/m2 | Baseline | 50.4 (4.6) | 50.8 (4.9) | 49.0 (7.6) | 48.8 (6.3) | 46.0 (6.1) | 46.0 (5.6) | 46.1 (6.4) | 46.1 (5.3) |
| Fat mass, % | Baseline | 47.9 (4.1) | 49.7 (4.9) | 45.3 (4.3) | 46.3 (5.5) | 45.5 (4.3) | 45.1 (7.6) | 45.3 (4.9) | 45.6 (6.2) |
| Glycemia, mmol/L | Baseline | 5.1 (1.0) | 6.0 (2.2) | 7.2 (2.7) | 6.3 (1.7) | 5.5 (1.3) | 6.1 (2.9) | 6.1 (1.7) | 6.4 (2.8) |
| Cholesterol, mmol/L | Baseline | 5.0 (1.3) | 4.8 (0.8) | 4.5 (0.8) | 4.5 (0.8) | 5.2 (1.0) | 5.0 (0.9) | 4.9 (0.8) | 5.1 (1.3) |
| Percentage of Weight, % | 3 months | 84.9 (6.5) | 84.1 (6.8) | 83.1 (7.6) | 81.3 (4.3) | 84.8 (4.6) | 83.3 (6.8) | 83.0 (3.7) | 82.4 (4.3) |
| 6 months | 80.0 (10) | 78.8 (9.2) | 76.1 (10.6) | 74.4 (5.6) | 78.9 (7.2) | 77.3 (8.3) | 76.5 (6.2) | 74.5 (5.9) | |
| 12 months | 74.1 (13.4) | 72.5 (10.4) | 70.9 (13.3) | 68.0 (7.1) | 74.3 (9.5) | 72.4 (10.5) | 70.2 (7.9) | 68.7 (6.8) | |
Data are mean (SD) or % when specified.
Difference between carriers and non-carriers were tested with Wilcoxon paired rank test.
*
p value<0.05.