Figure 6. In vivo therapeutic efficacy of V1801 on mice bearing gefitinib-resistant NSCLC cells.

(a) Nude mice inoculated subcutaneously with NCI-H1975 cells were treated with gefitinib or V1801 for 3 weeks, and caliper measurements of the longest perpendicular tumor diameters were performed every two days to estimate the tumor volume. (b) Images of mice two weeks after initiation of the treatment. (c) Images of xenograft tumors obtained from mice. Eight representative tumors for each treatment group are shown. (d, e) Western blot analysis of lysates of tumor samples using indicated antibodies (d). Noxa expression was quantified by densitometry analysis and normalized against Actin expression (e).