Table 1. estimates of lifetime cost per incident patient by diagnosis.

Conditions	Surgical procedures and medical treatments	Direct cost per procedure or medical treatment	Compound Consumer Price Index rate Ŧ	Lifetime direct costs per incident patient (2011 Euro)	References
		a	B	a × b
Cervical cancer	Management of primary tumor	€ 13,122	110.60%	€ 14,513	[11]
	Discounted cost of progression/recurrence after 1 year	€ 8,827	110.60%	€ 9,763	[11]
	Lifetime cost per patient	€ 21,950	110.60%	€ 24,276
Cervical dysplasia	Repeated Pap smears	€ 15	110.60%	€ 17	[15]
	Management of abnormal Pap smears	€ 250	110.60%	€ 277	[15]
	Diagnosis of cervical dysplasia	€ 34	112.92%	€ 38	[12]
	CIN 1 treatment	€ 262	112.92%	€ 296	[12]
	CIN2 treatment	€ 1,439	112.92%	€ 1,625	[12]
	CIN3 treatment	€ 2,011	112.92%	€ 2,271	[12]
Anal cancer †	Diagnosis of malignancy	€ 1,421	110.60%	€ 1,572	DRG 411 [22]
	Anal surgery	€ 3,245	110.60%	€ 3,589	DRG 157 [22]
	Radiotherapy	€ 3,096	110.60%	€ 3,424	DRG 409 [22]
	Minor reconstructive surgery	€ 2,460	110.60%	€ 2,720	DRG 266 [22]
	Follow-up clinical examination (×2)	€ 21	110.60%	€ 46	Outpatient tariff 89.7 [23]
	Follow-up 2-sector CT scan (×2)	€ 88	110.60%	€ 391	Outpatient tariff 88.01.3 [23]
	Lifetime cost per patient			€ 11,742
Head and neck cancer †	Diagnosis of head and neck malignancy	€ 3,292	110.60%	€ 3,641	DRG 64 [22]
	Head and neck surgery	€ 7,512	110.60%	€ 8,308	DRG 49 [22]
	Radiotherapy	€ 3,096	110.60%	€ 3,424	DRG 409 [22]
	Minor reconstructive surgery	€ 2,460	110.60%	€ 2,720	DRG 266 [22]
	Follow-up clinical examination (×2)	€ 21	110.60%	€ 46	Outpatient tariff 89.7 [23]
	Follow-up 2-sector CT scan (×2)	€ 83	110.60%	€ 368	Outpatient tariff 88.01.3 [23]
	Lifetime cost per patient			€ 18,507
Vulvar cancer ††	Diagnosis of malignancy	€ 1,421	110.60%	€ 1,572	DRG 411 [26]
	Minor vulvectomy	€ 7,141	110.60%	€ 7,898	DRG 353 [26]
	Radiotherapy	€ 3,096	110.60%	€ 3,424	DRG 409 [26]
	Follow-up clinical examination (×2)	€ 21	110.60%	€ 46	Outpatient tariff 89.26 [27]
	Follow-up 2-sector CT scan (×2)	€ 88	110.60%	€ 391	Outpatient tariff 88.01.3 [27]
	Lifetime cost per patient			€ 13,330
Vaginal cancer ††	Diagnosis of malignancy	€ 1,421	110.60%	€ 1,572	DRG 411 [22]
	Vaginal surgery	€ 6,736	110.60%	€ 7,450	DRG 354 [22]
	Minor reconstructive surgery	€ 2,734	110.60%	€ 3,024	DRG 356 [22]
	Radiotherapy	€ 3,096	110.60%	€ 3,424	DRG 409 [22]
	Follow-up clinical examination (×2)	€ 21	110.60%	€ 46	Outpatient tariff 89.26 [23]
	Follow-up 2-sector CT scan (×2)	€ 88	110.60%	€ 391	Outpatient tariff 88.01.3 [23]
	Lifetime cost per patient			€ 15,906
Penile cancer †††	Diagnosis of malignancy	€ 1,421	110.60%	€ 1,572	DRG 411 [22]
	Surgery	€ 4,173	110.60%	€ 4,616	DRG 344 [22]
	Radiotherapy	€ 3,096	110.60%	€ 3,424	DRG 409 [22]
	Follow-up clinical examination (×2)	€ 21	110.60%	€ 46	Outpatient tariff 89.7 [23]
	Follow-up 2-sector CT scan (×2)	€ 88	110.60%	€ 391	Outpatient tariff 88.01.3 [23]
	Lifetime cost per patient			€ 10,048
Anogenital warts (women)	Direct outpatient costs for new patients	€ 368	112.92%	€ 416	[19]
	Discounted cost of recurrence after 1 year (50.6% prob.)	€ 176	112.92%	€ 199	[19]
	Discounted cost of resistance after 1 year (28.2% prob.)	€ 43	112.92%	€ 48	[19]
	Lifetime cost per female patient	€ 587	112.92%	€ 663	[19]
Anogenital warts (men)	Direct outpatient costs for new patients	€ 275	112.92%	€ 311	[19]
	Discounted cost of recurrence after 1 year (34.8% prob.)	€ 59	112.92%	€ 66	[19]
	Discounted cost of resistance after 1 year (38.5% prob.)	€ 82	112.92%	€ 92	[19]
	Lifetime cost per male patient	€ 416	112.92%	€ 470
RRP ‡, ††††	Management of complicated throat infection	€ 5,930	110.60%	€ 6,559	DRG 79 [22]
	Acute clinical treatment of throat infection (×3)	€ 7,006	110.60%	€ 23,246	DRG 76 [22]
	Minor throat surgery (×4.4)	€ 3,263	110.60%	€ 15,878	DRG 63 [22]
	Tracheostomy (11% rate)	€ 9,040	110.60%	€ 1,100	DRG 75 [22]
	Annual cost per patient			€ 46,783
	Lifetime cost per patient			€ 187,428

Ŧ. Costs have been adjusted for inflation at 2011 values using compound annual Italian National Consumer Price Indexes (ISTAT reference) from 2005 (112.92%) or 2006 (110.6%).

^†. Surgical procedures and medical treatments were modelled on the basis of the Italian AIOM guidelines [16].

^††. Surgical procedures and medical treatments were modelled on the basis of the Italian SIGO guidelines [17].

^†††. Surgical procedures and medical treatments were modelled on the basis of the Italian AIRC guidelines [18.].

^‡Respiratory recurrent papillomatosis (RRP).

^††††. Due to the lack of Italian data on RRP, surgical procedures and medical treatments were informed on the basis of U.S. data [20], [21].