Table 2. Estimates of total lifetime cost per case.

	Conditions	Lifetime direct costs per incident patient (2012 Euro)	Estimated incident cases per year	Lower bound	Upper bound	Total lifetime direct costs per diagnosis (mill Euro)	Lower bound	Upper bound	References
		a	b	C	d	a × b	a × c	a × d
e	Cervical cancer	€ 24,276	3,029	2,754	3,304	€ 73.5	€ 66.9	€ 80.2	[26]
f	Repeated Pap smears	€ 17	415,000	-	-	€ 6.9	€ 6.9	€ 6.9	[15]
g	Management of abnormal Pap smears	€ 277	116,000	-	-	€ 32.1	€ 32.1	€ 32.1	[15]
h	Diagnosis of cervical dysplasia	€ 38	390,000	-	-	€ 14.9	€ 14.9	€ 14.9	[12]
i	CIN 1 treatment	€ 296	21,308	-	-	€ 6.3	€ 6.3	€ 6.3	[12]
l	CIN2 treatment	€ 1,625	3,218	3,218	7,638	€ 5.2	€ 5.2	€ 12.4	[12], [34]
m	CIN3 treatment	€ 2,271	3,518	3,518	8,350	€ 8.0	€ 8.0	€ 19.0	[12], [34]
n	Total cervical lesions (h + i + l + m)					€ 34.4	€ 34.4	€ 52.6
o	Total cervical dysplasia (f + g + n)					€ 73.4	€ 73.4	€ 91.5
p	Total cervical conditions (e + o)					€ 146.9	€ 140.2	€ 171.7
q	Anal cancer	€ 11,742	889	704	1,075	€ 10.4	€ 8.3	€ 12.6	[26]
r	Head and neck cancer	€ 18,507	12,106	10,140	14,073	€ 224.0	€ 187.7	€ 260.5	[26]
s	Vulvar cancer	€ 13,330	1,134	983	1,284	€ 15.1	€ 13.1	€ 17.1	[26]
t	Vaginal cancer	€ 15,906	251	207	295	€ 4.0	€ 3.3	€ 4.7	[26]
u	Penile cancer	€ 10,048	380	324	435	€ 3.8	€ 3.3	€ 4.4	[26]
v	Total anogenital warts (women)	€ 663	62,250	-	-	€ 41.3	€ 41.3	€ 41.3	[13], [19], [27]
z	Total anogenital warts (men)	€ 470	80,000	-	-	€ 37.6	€ 37.6	€ 37.6	[13], [19], [27]
y	RRP ‡	€ 187,428	243	243	728	€ 45.5	€ 45.5	€ 136.4	[7], [8]
w	Total non-cervical conditions (q + r + s + t + u + v + z + y)					€ 381.7	€ 339.9	€ 514.4
	Total burden (p + w)					€ 528.6	€ 480.1	€ 686.2

^‡Respiratory recurrent papillomatosis (RRP).