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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: J Immunol. 2012 Oct 24;189(11):5257–5265. doi: 10.4049/jimmunol.1201905

FIGURE 2.

FIGURE 2

HIV-1 gp120 inhibits CpG-B-induced pDC maturation. (A) pDCs were treated with CpG-B in the presence or absence of JR-FL gp120 and stained with MAbs against CD40, CD83, CCR7 and HLA-DR. The black curve represents untreated pDCs; green curve, JR-FL gp120-treated pDCs; red curve, CpG-B-treated pDCs; blue curve, CpG-B and JR-FL gp120-treated pDCs. (B) Expression of CD40, CD83, CCR7 and HLA-DR in CpG-B and JR-FL gp120-treated pDCs relative to CpG-B-treated pDCs. The data shown represent the mean values ± SEM obtained using pDCs from at least four individual donors.