Table 1. Results of laboratory tests in four patients with HBV-associated acute liver failure.

	Massive Hepatic Necrosis (MHN)				Submassive Hepatic Necrosis (MHN)
	Patient 241		Patient 31		Patient 219		Patient 32
Variable	On Admission	Before OLT	On Admission	Before OLT	On Admission	Before OLT	On Admission	Before OLT
Platelet count (per mm3)	90,000	93,000	119,000	196,000	192,000	91,000	109,000	141,000
Creatinine (mg/dL)	0.6	1.0	0.9	0.8	2.6	3.7	1.0	1.0
Prothrombin time (INR) †	11.0	4.5	6.7	4.6	11.5	4.6	4.4	2.5
Bilirubin (mg/dL)
Total	9.8	20.6	8.9	10.8	5.2	10.4	11.7	13.6
Conjugated		2.2	4.3	2.3	3.2	4.5	10.2	6.9
Aspartate aminotransferase (U/L)	4,000	34	9,793	924	4,565	194	6,544	1,114
Alanine aminotransferase (U/L)	5,700	252	7,573	2,537	4,710	762	11,630	2,402
Alkaline phosphatase (U/L)		167	542	401	326	291	296	290
Lactate dehydrogenase (U/L)	1,460	603	4,972	449	1,411	822	6,481	846
γ-Glutamyltransferase (U/L)		27	80	47	39	36	165	109
Alphafetoprotein (ng/mL) ‡		2.5		1.21		3.5		105.5
Serology for viral hepatitis A, C, D	Negative		Negative		Negative		Negative
HBsAg	Positive	Negative	Positive	Positive	Positive	NA	Borderline	Negative
Concentration (µg/mL)				1.74
Anti-HBs (mIU/mL)	0.6	67.7	0	0	15.3		5.9	8.0
Anti-HBc	Positive	Positive	Positive	Positive	Positive	NA	Positive	Positive
IgM anti-HBc	Positive	Positive	Positive	Positive	Positive	NA	Positive	Positive
HBeAg	NA	Negative	Negative	Negative	Positive	NA	Negative	Negative
Anti-HBe	NA	Positive	Borderline	Positive	Positive	NA	Positive	Positive
HBV DNA (copies/mL)	760	291		218,000	19,284		185,000	7,500
HDV RNA	Negative		Negative		Negative		Negative
HCV RNA	Negative		Negative		Negative		Negative

To convert the values for creatinine to µmol/L, multiply by 88.4; to convert the values for total and conjugated bilirubin to µmol/L, multiply by 17.1.

^†Normal range, 0.80 to 1.20 international normalized ratio (INR).

^‡Normal range, <10.0 ng/mL. NA denotes not available.