Figure 5. Reduced detection sensitivity to 1-octanol and 2-heptanone in ERK5 icKO mice.

ERK5 icKO and control mice were presented with 2 cotton swabs, one laced with vehicle control and the other with increasing concentrations of 1-octanol or 2-heptanone. An above 50% sniffing duration (above chance) indicates detection of 1-octanol or 2-heptanone at that specific concentration. A) Dose-response of detection threshold to 1-octanol, a chemically defined odorant. B) Dose-response of detection threshold to 2-heptanone, a chemically defined mouse pheromone. n ≥14 mice per treatment group.