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Cryo-TEM analysis of PEGylated liposomes of (a) doxorubicin sulfate (Doxil®) and (b) doxorubicin glucuronate (Dox-G), prepared by diffusion across a pH gradient [8, 73]. Encapsulated doxorubicin sulfate crystallized into nanorods whereas Dox-G did not, with an apparent impact on pharmacokinetics. © 2012 Elsevier (reprinted with permission) [8].
