Figure 3.

Regions where the relationship between COMT Val158Met Val allele dose and cortical thickness change is significantly different in healthy controls (HCs) as compared to probands with childhood-onset schizophrenia (COS). The inset plot illustrates this interaction for the left dorsolateral prefrontal region, where increased Val dose attenuates cortical thinning on HCs, but accelerates it in probands with COS. Note that by adulthood, COS Val homozygotes have persistent cortical thickness deficits compared with HCs, whereas Met homozygotes do not. All colored regions shown survive false discovery rate correction for multiple comparisons at q < 0.05.⁸⁵