Table 1.
Demographic features, gross brain weight (BW), Braak tangle stage, and disease subtype of the ten cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP).
| Case | Centre | Sex | Onset | Death | Duration | BW | Braak | Assigned |
|---|---|---|---|---|---|---|---|---|
| stage | ST | |||||||
| A | H | F | 80 | 88 | 8 | 1035 | III | 2 |
| B | H | M | 73 | 79 | 6 | 1180 | II | 3 |
| C | V | F | - | 82 | - | 940 | 0 | 1 |
| D | V | M | 69 | 72 | 3 | - | 0 | 2 |
| E | V | M | 66 | 71 | 5 | 1230 | II | 3 |
| F | V | F | 55 | 70 | 15 | - | III | 1 |
| G* | V | M | 70 | 71 | 1 | 1140 | IV | 2 |
| H | P | M | 61 | 65 | 4 | 1100 | II | 2 |
| I | P | M | - | 76 | - | 1440 | III | 1 |
| J | P | M | 61 | 64 | 3 | 1330 | I | 2 |
Abbreviations: H = Harvard Brain Tissue Resource Center, V = Vancouver General Hospital, P = Department of Pathology, University of Pittsburgh, M = Male, F = Female, Disease onset, age at death, and disease duration are given in years, BW = Brain weight (gm), Braak stage represents staging of Alzheimer disease-associated neurofibrillary pathology, ST = previously assigned disease subtype according to Cairns et al (2007).
(-)= data not available,
*
Case with associated motor neuron disease (MND)