Table I.

Parameter estimates for CD4⁺ T cell dynamics.^a

parameter	symbol	unit	Model A		Model B		Model C
Proliferation rate	ρLLO118	day−1	0.99	[0.97,1.01]	1.05	[1.03,1.07]	1.03	[1.01,1.05]
	ρLLO56		0.91	[0.88,0.93]	0.91	[0.88,0.93]	0.95	[0.93,0.97]
Memory cell formation	rLLO118	day−1	0.20	[0.15,0.24]	0.03	[0.02,0.03]	0.31	[0.28,0.34]
	rLLO56		0.11	[0.08,0.12]	0.04	[0.03,0.04]	0.33	[0.31,0.35]
Activated cells at t = 0	A(0)LLO118	cells	148	[140,155]	147	[140,155]	152	[144,159]
	A(0)LLO56		80	[74,86]	82	[76,88]	63	[59,67]
Death rate of memory cells	${\delta }_M^{\mathit{LLO}118}$	day−1	0.16	[0.16,0.17]	0.14	[0.13,0.15]	0.14	[0.13,0.15]
	${\delta }_M^{\mathit{LLO}56}$		0.06	[0.05,0.07]	0.06	[0.05,0.06]	0.05	[0.04,0.06]
Death rate of activated cells	δA	day−1	1.37	[1.07,1.66]	0.68	[0.61,0.74]	0.51	[0.47,0.54]
End of proliferation phase	T	day	7.4	[7.2,7.5]	7.1	[7,7.2]	6.7	[6.6,6.8]
residual mean square	MNSQ		3.381		3.393		3.393

^aParameter estimates for the basic model ((A), Eqs. (1a) and (1b)), for a model assuming constant memory cell production during the proliferation phase ((B), Eqs. (4a) and (4b)), and for a model assuming the alternative differentiation pathway ((C), Eqs. (5a) and (5b)). 95% confidence intervals for the estimates are calculated based on the standard error approximated by the Hessian-matrix. MNSQ indicates the residual mean square for each model (see Materials and Methods for the calculation).