Table II.
CD5 level and proliferation rates.a
| parameter | symbol | unit | Model A | Model B | Model C |
|---|---|---|---|---|---|
| Proliferation rate | ρ̂LLO118 | day−1 | 1.38 | 1.10 | 1.21 |
| [1.21,1.54] | [1.00,1.20] | [1.06,1.35] | |||
| ρ̂LLO56 | 1.39 | 1.05 | 1.22 | ||
| [1.22,1.56] | [0.95,1.14] | [1.07,1.37] | |||
| Scaling constant | γ | log(m.f.u.)−1 | 0.045 | 0.005 | 0.020 |
a
Estimated proliferation rates with the assumption of a negative effect of the CD5 level on proliferation. To investigate the influence of the CD5 expression level on the proliferation rate, ρ was replaced by ρ̂/(γ log(cd5)+1), with γ a scaling constant and cd5 the individual CD5 expression level. All other parameters in the model were kept fixed to the values estimated in Table I. 95% confidence intervals for the estimates are calculated based on the standard error approximated by the Hessian-matrix.