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Schematic diagram of the development of the 5q-syndrome. The roles of the haploinsufficiency of RPS14, miR145, and miR146 and possible progression to AML by adjunct cytogenetic abnormalities are shown. Fli1 upregulation stimulates transcriptionally HDM2 [109] and inhibits partially p53 activation caused by ribosomal stress resulting from RPS14 haploinsufficiency.
