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. 2012 Nov 21;151(5):964–980. doi: 10.1016/j.cell.2012.10.040

Figure S5.

Figure S5

Related to Figure 7

(A and B) Shown are normalized density profiles of Pol II ChIP-seq (red), GRO-seq (black), RNA-seq (brown) and H3K9me3 ChIP-seq (green) for the indicated OSC knockdowns (left).

(A) Shown is the ∼140kb area with an mdg1 insertion upstream of the typically non-expressed gene CG15278. Upon loss of the piRNA pathway transcriptional bleeding from the TE insertion into the CG15278 locus leads to accumulation of RNA reads.

(B) Shown is a ∼120kb area with a 17.6 insertion in sense orientation into an intron of the Btk29A transcription unit. This insertion triggers H3K9me3 spreading, which depends on Piwi but only weakly on Mael. Loss of the piRNA pathway does not lead to upregulation of the host gene, classifying this insertion.