Table 5.
Direct HLA interactions of KIR2DS1 and KIR2DS2.
| Allele | Polymorphism | Effect | Reference |
|---|---|---|---|
| 2DL2/3 | P16R + R148C | Increased binding/function of 2DL2 to C1 and C2 allotypes | Moesta et al. (2008) |
| 2DL2*004 | T41R | Disruption of D1 folding leads to down regulation of cell-surface expression | VandenBussche et al. (2006) |
| 2DL2*005 | A333T | Single-nucleotide polymorphism (SNP) association with Type 1 Diabetes (T1D) | Ramos-Lopez et al. (2009) |
| 2DL1 | R245C | Transmembrane R245 increases SHP-2 binding to 2DL1*003 and 2DL1*010 leading to stronger inhibition | Bari et al. (2009) |
| 2DL3*009 | R148P | Weaker binding to C1 allotypes | Gendzekhadze et al. (2009) |