Table 7.
Associations of KIR2DL2/3 with autoimmune disease.
| Disease associated and HLA factors | Reference | |
|---|---|---|
| KIR associations | ||
| Psoriatic arthritis | Presence of 2DS1 is associated with disease | Williams et al. (2005) |
| Scleroderma | Presence of 2DS2, absence of 2DL2 predisposes to disease | Momot et al. (2004) |
| Scleroderma | Presence of 2DS1 and/or 2DS2 is increased in diseased individuals | Pellett et al. (2007) |
| Type 1 diabetes | Presence of 2DL2 and 2DS2 positively correlates with disease | Nikitina-Zake et al. (2004) |
| Type 1 diabetes | SNP coding for A333T polymorphism in 2DL2 is associated with disease | Ramos-Lopez et al. (2009) |
| Rheumatoid arthritis | Increased frequency of 2DS2 expression on NK cells and T cells in patients that develop vasculitis; relevant expression is thought to be on CD4+CD28- T cells | Yen et al. (2001) |
| Systemic lupus erythematosus | Frequency of 2DL2 and 2DS1 are increased in SLE patients | Hou et al. (2010) |
| Systemic lupus erythematosus | Presence of 2DS1 with absence of 2DS2 is associated with disease | Pellett et al. (2007) |
| KIR + HLA associations | ||
| Crohn’s disease | 2DL2/3 heterozygosity + C2 homozygosity is protective; 2DL2/3 heterozygosity + presence of C1 is predisposing | Hollenbach et al. (2009) |
| Ulcerative colitis | 2DL2/2DS2 are overrepresented in patients; 2DL3 in the presence of C1 is protective | Jones et al. (2006) |
| Psoriatic arthritis | Susceptibility determined by combinations of /HLA combinations; absence of inhibitory HLA ligands is predisposing | Nelson et al. (2004) |
| Psoriasis vulgaris | 2DS1 and KIRB haplotypes are correlated with disease | Suzuki et al. (2004) Luszczek et al. (2004) |
| Type 1 diabetes | 2DS2 and C1 predisposes to disease; 2DL1 and C2 is protective | van der Slik et al. (2003) |
| Type 1 diabetes | Combination of 2DL2 and C2 confers susceptibility, absence of 2DL2 and C2 is protective. Either effect is stronger in the absence of 2DS1 and 2DS2 | Shastry et al. (2008) |
| Sjogren’s syndrome | Presence of 2DS2, in absence of 2DL2 predisposes to disease. Effect is strongest when C1 is present | Lowe et al. (2009) |
| Multiple sclerosis | 2DS1 is protective; effect is stronger in the presence of C2 | Fusco et al. (2010) |