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6-mercaptopurine (6-MP) intracellular pathways with polymorphisms suggested to increase the occurrence of adverse effects. SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine; TPMT, thiopurine S-methyltransferase; XO, xanthine oxidase; 6-Me-MP, 6-methyl-mercaptopurine; 6-TIMP, 6-thioinosine monophosphate; 6-TITP, 6-thioinosine triphosphate; ITPA, inosine triphosphate pyrophosphatase; 6-MMPN, 6-methyl-mercaptopurine nucleotides; 6-TGN, 6-thioguanine nucleotides
