Table 2.
Major susceptibility genes associated with tuberculosis [141, 142] and primary biliary cirrhosis [133–140], as reported through genome wide association studies. Note that no positive associations are significantly shared between primary biliary cirrhosis (PBC) and pulmonary tuberculosis (TB).
| Gene | PBC | TB |
|---|---|---|
| HLA | ||
| DR8 | + | − |
| DQB1 | + | − |
| DRB1 | + | − |
| DQA1 | + | − |
| DQA2 | + | − |
| Non-HLA | ||
| STAT4 | + | − |
| SPIB | + | − |
| IRF5 | + | − |
| IL12A | + | − |
| IL12RB | + | − |
| MMEL1 | + | − |
| CXCR5 | + | − |
| NFKB1 | + | − |
| JAG1 | − | + |
| DYNLRB2 | − | + |
| EBF1 | − | + |
| TMEFF2 | − | + |
| CCL17 | − | + |
| HAUS6 | − | + |
| PENK | − | + |
| TXNDC4 | − | + |