Table 3.
Biodistribution of 99mTc-Clomiphene in Swiss albino solid tumor bearing mice at different time intervals after injection.
| Organs and body fluids | Percent ID/organ | ||||
|---|---|---|---|---|---|
| Time after injection | |||||
| 15 min |
30 min | 1 hr | 4 hr | 24 hr | |
| Blood | 16.8 ± 1.8 | 13.8 ± 0.9 | 6.4 ± 1.1 | 3.2 ± 0.5 | 2.3 ± 0.7 |
| Kidneys | 18.9 ± 0.9 | 18.2 ± 0.9 | 13.8 ± 1.3 | 9.1 ± 1.3 | 3.8 ± 0.7 |
| Liver | 4.4 ± 0.27 | 3.2 ± 0.1 | 3.5 ± 0.1 | 3.3 ± 0.4 | 2.1 ± 0.1 |
| Spleen | 1.7 ± 0.1 | 1.8 ± 0.4 | 2.1 ± 0.7 | 1.6 ± 0.25 | 1.2 ± 0.4 |
| Intestine | 5.2 ± 0.2 | 5.2 ± 1.3 | 6.9 ± 1.2 | 7.2 ± 0.9 | 7.5 ± 0.5 |
| Stomach | 8.1 ± 0.6 | 9.8 ± 1.2 | 11.8 ± 0.5 | 12.3 ± 1.1 | 5.5 ± 1.2 |
| Lungs | 5.5 ± 0.1 | 3.3 ± 0.5 | 1.9 ± 0.4 | 1.7 ± 0.7 | 1.9 ± 0.6 |
| Heart | 7.0 ± 0.8 | 4.5 ± 1.5 | 2.5 ± 0.7 | 2.2 ± 0.7 | 1.1 ± 0.4 |
| Thyroid | 0.8 ± 0.02 | 1.2 ± 0.4 | 1.3 ± 0.7 | 1.7 ± 0.23 | 0.6 ± 0.3 |
| Normal muscle | 0.8 ± 0.05 | 2.9 ± 0.6 | 2.3 ± 0.6 | 3.1 ± 0.9 | 2.9 ± 0.5 |
| Bone | 1.2 ± 0.1 | 1.6 ± 0.5 | 1.4 ± 0.7 | 1.2 ± 0.4 | 0.7 ± 0.5 |
| Tumor muscle | 2.7 ± 0.2 | 5.6 ± 0.9 | 12.5 ± 1.8 | 8.8 ± 1.1 | 4.2 ± 0.9 |
% ID/gram ± S.D, n = 6.