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Network motifs for induction and maintenance of lineage commitment. Simplified examples of molecular mechanisms and networks of stable commitment induction and propagation in erythroid (A), B-lymphoid (B), T-lymphoid (C), and myeloid (D) cells. Direct or indirect activation (arrows) and repression (barred lines) of individual factor expression are indicated. Transcription factors are depicted in white, surface receptors in gray. Dashed lines represent indirect interactions.
