Figure 6.

Blocking ERK1/2 activation by treatment with U0126 decreases OA-induced lung inflammation. Treatment protocols are described in Methods. Neutrophils (a) and lipid body formation (b). The following cytokines were also measured: IL-6 (c) and IL-1β (d). Controls received the same volume of saline. All measurements were performed 24 h after OA challenge. Results are expressed as mean ± SEM from at least 6 animals. *P < 0.05 compared to control group; **P < 0.05 compared to OA stimulated group.