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. 2012 Sep 24;55(20):8603–8614. doi: 10.1021/jm300801u

Figure 1.

Figure 1

(a) Extracellular domains of two adjacent subunits of the 5-HT3 receptor. (b) Pharmacophore features for 5-HT3 receptor antagonists. A, B and C indicate respectively an aromatic part, a basic moiety and a hydrogen bond acceptor. (c) Structure of hit fragment VUF10434 (1).