Scheme 3. Preparation of Quinoline Compounds 30 and 31.
Reagents: (a) Aqueous NH4OH, 140 °C; (b) MeNH2, DiPEA, EtOAc, 100 °C; (c) N-methylpiperazine, THF or neat, 160 °C.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.