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. 2012 Sep 24;55(20):8603–8614. doi: 10.1021/jm300801u

Scheme 4. Preparation of 1-Methyl-4-(naphthalen-2-yl)piperazine (33).

Scheme 4

Reagents: (a) N-Methylpiperazine, n-BuLi, 0 °C, then 2-methoxynaphthalene (32), THF, rt.