Scheme 5. Preparation of 3-(4-Methylpiperazin-1-yl)quinoline (35).
Reagents: (a) NaNH2, t-BuOH, THF, 0 °C, N-methylpiperazine, 40 °C, then 3-bromoquinoline (34), 0 °C to rt.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.