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. 2012 Sep 24;55(20):8603–8614. doi: 10.1021/jm300801u

Scheme 7. Preparation of Quinolines 46 and 47.

Scheme 7

Reagents: (a) H2SO4, KNO3, 0 °C to rt; (b) N-methylpiperazine, 140 °C; (c) H2, Pd/C, MeOH, rt.