. 2012 Sep 24;55(20):8603–8614. doi: 10.1021/jm300801u

Table 3. Effect of R³ = Cl or R³ = H on the 5-HT₃AR Affinity.

#	R²	R³	pK_i^a
11	H	Cl	8.13 ± 0.27
49	H	H	8.87 ± 0.10
48	OH	Cl	6.24 ± 0.24
26	OH	H	7.33 ± 0.12
12	NH₂	Cl	7.92 ± 0.09
22	NH₂	H	10.29 ± 0.15
6	NMe	Cl	8.95 ± 0.05
21	NMe	H	8.53 ± 0.05

Determined by radioligand competition using [³H]granisetron.

Table 3. Effect of R3 = Cl or R3 = H on the 5-HT3AR Affinity.