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STAT3 blockade by siRNA induces TrkB and Akt dependency in neurons. A, Immunostaining of GFP, STAT3, p53, and Bax. Neurons (DIV9) were cotransfected with a plasmid containing cDNA of GFP and STAT3 siRNA. B, Number of neurons after incubation with 5 μg/ml anti-TrkB, or 25 μm LY294002 (and 10 ng/ml BDNF) for 2 d (DIV12 to DIV14). Numbers of neurons in control were taken as 100% (n = 5). *p < 0.05. Error bars indicate SEM.
