Table 1.
Physical characteristics of study participants1.
| Participants who completed the study (n=46) |
Participants selected for the comet assay (n=20) |
|||
|---|---|---|---|---|
| Mean | SEM | Mean | SEM | |
| Age | 56.0 | 1.5 | 53.9 | 2.4 |
| BMI | 29.1 | 0.9 | 28.3 | 0.9 |
| Number | % of Total | Number | % of Total | |
| Sex | ||||
| Female | 34 | 73.9 | 12 | 60 |
| Male | 12 | 26.1 | 8 | 40 |
| Ethnicity | ||||
| African-American | 14 | 30.4 | 5 | 25 |
| Asian | 1 | 2.2 | 1 | 5 |
| Caucasian | 30 | 65.2 | 14 | 70 |
| Hispanic | 1 | 2.2 | 0 | 0 |
| Genotype | ||||
| XPD Codon 312 | ||||
| Asn/Asn | 4 | 8.7 | 4 | 20 |
| Asp/Asn | 22 | 47.8 | 14 | 70 |
| Asp/Asp | 20 | 43.5 | 2 | 10 |
| XPD Codon 751 | ||||
| Gln/Gln | 9 | 19.6 | 7 | 35 |
| Lys/Gln | 26 | 56.5 | 13 | 65 |
| Lys/Lys | 11 | 23.9 | 0 | 0 |
| GSTM1 | ||||
| GSTM1-null | 19 | 41.3 | 9 | 45 |
| GSTM1+ | 27 | 58.7 | 11 | 55 |
| GSTT1 | ||||
| GSTT1-null | 9 | 19.6 | 1 | 5 |
| GSTT1+ | 37 | 80.4 | 19 | 95 |
1
Forty-six participants completed the study. For twenty of those participants, PBMCs were collected on the final day of each treatment period immediately before treatment consumption and at 3 and 6 hours after consumption, and PBMC samples were subsequently assessed for DNA strand breaks by the comet assay.