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. Author manuscript; available in PMC: 2012 Nov 23.
Published in final edited form as: Toxicol Pathol. 2012 May 23;40(8):1095–1105. doi: 10.1177/0192623312447551

Figure 6.

Figure 6

Loss of Mkp-1 function prolongs hepatic JNK MAPK activation. Liver homogenates were prepared from fasted Mkp-1+/+ and Mkp-1−/− mice treated with vehicle or 300 mg/kg acetaminophen and euthanized at the time points indicated. Homogenates were probed with antibodies against p-JNK, JNK1, p-p38, and p38. (A) Scans of representative Western blot radiographs. (B) Densitometry histograms of scans for p-JNK1 and p-JNK2 in part (A) normalized to JNK1. (C) Densitometry histograms of scans for p-p38 in part (A) normalized to total p38. Values represent mean ± standard error from three mice; n = 3–5 mice/group over all blots performed. *p < .05.