Table 5.
Regression coefficients and 95% confidence intervals for the association between hysterectomy and waist circumference (WC) (cm) at ages 43 and 53 years in the 1946 cohort and at age 44/45 years in the 1958 cohort adjusted separately for: (a) age at menarche, (b) parity, (c) lifetime socioeconomic position, (d) exercise in adulthood and (e) hormone replacement therapy use
| Adjusted for | 1946 cohort |
1958 cohort |
||||
|---|---|---|---|---|---|---|
| Regression coefficient (difference in mean WC at age 43 years) (95% CI) | p-Value* | Regression coefficient (difference in mean WC at age 53 years) (95% CI) | p-Value* | Regression coefficient (difference in mean WC at age 44/45y) (95% CI) | p-Value* | |
| Age at menarche | N = 1275 | N = 1202 | N = 2854 | |||
| Unadjusted | 0.27 (−1.87, 2.41) | 0.81 | 1.06 (−0.72, 2.85) | 0.24 | 2.57 (1.05, 4.09) | 0.001 |
| Adjusted | −0.14 (−2.26, 1.98) | 0.90 | 0.79 (−0.99, 2.57) | 0.38 | 2.31 (0.82, 3.81) | 0.002 |
| Parity | N = 1580 | N = 1475 | N = 3925 | |||
| Unadjusted | 0.33 (−1.59, 2.25) | 0.74 | 1.44 (−0.16, 3.04) | 0.08 | 2.64 (1.28, 4.00) | <0.001 |
| Adjusted | 0.27 (−1.65, 2.19) | 0.78 | 1.24 (−0.37, 2.84) | 0.13 | 2.61 (1.25, 3.97) | <0.001 |
| Lifetime socioeconomic position | N = 1366 | N = 1285 | N = 3682 | |||
| Unadjusted | 0.44 (−1.55, 2.44) | 0.67 | 1.85 (0.13, 3.57) | 0.04 | 2.04 (0.63, 3.46) | 0.005 |
| Adjusted | 0.06 (−1.91, 2.03) | 0.95 | 1.52 (−0.17, 3.21) | 0.08 | 1.54 (0.13, 2.95) | 0.03 |
| Exercise in adulthood | N = 1455 | N = 1347 | N = 3926 | |||
| Unadjusted | 0.66 (−1.35, 2.67) | 0.52 | 1.66 (−0.004, 3.33) | 0.05 | 2.51 (1.14, 3.88) | <0.001 |
| Adjusted | 0.83 (−1.13, 2.80) | 0.41 | 1.53 (−0.09, 3.15) | 0.06 | 2.30 (0.94, 3.66) | 0.001 |
| Hormone replacement therapy use | N = 1402 | N = 1476 | N = 4424 | |||
| Unadjusted | 0.70 (−1.38, 2.77) | 0.51 | 1.45 (−0.15, 3.05) | 0.08 | 2.61 (1.33, 3.89) | <0.001 |
| Adjusted | 1.08 (−1.02, 3.18) | 0.31 | 2.32 (0.64, 4.00) | 0.01 | 1.99 (0.58, 3.39) | 0.005 |
Regression coefficients represent the differences in mean WC (cm) between the women who had undergone hysterectomy by the time of WC outcome measurement and women who had not undergone hysterectomy or oophorectomy by the time of WC outcome measurement. Note 1: The reference group is women who had not undergone hysterectomy or oophorectomy by the time of WC outcome measurement. Note 2: The same N is used for unadjusted analysis as is used for the corresponding adjusted analysis to ensure comparability of models.
p-Values from significance tests of the differences in mean waist circumference.