FIGURE 3.

The CthPnkp kinase domain crystallized as a homodimer. (A) The two CthPnk-(1-170) protomers in the asymmetric unit of the SeMet-kinase crystal are shown with protomers A and B colored green and magenta, respectively. The ATP in the active site is depicted as a stick model. N and C denote the N and C termini. (B) Stereoview of the dimer interface highlighting cross-protomer atomic contacts. Amino acid side-chains are shown as stick models. Ionic and hydrogen-bonding interactions are indicated by black dashed lines; van der Waals contacts are denoted by orange dashed lines.