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. 2012 Jun 29;19(12):1983–1991. doi: 10.1038/cdd.2012.86

Figure 8.

Figure 8

Whereas sc-tPA modulates neuronal synaptic plasticity through NMDAR signaling, tc-tPA does not. (a) LTP was recorded in the hippocampal CA1 area in the presence or absence of sc-tPA (100 nM, white dots, n=13) and tc-tPA (100 nM, black triangles, n=13). APV is used as a control to block NMDA receptors. (b) LTD induced alone (gray squares, n=9) or in the presence of either sc-tPA (100 nM, white dots, n=10) or tc-tPA (100 nM, black triangles, n=8). In inserts (a and b), fEPSPs recorded before and 50 min after stimulation. Statistical analysis was done for this interval using ANOVA repeated measures (**P<0.02; ***P<0.01)