Table 3.
Prevalence of Clinical Manifestations and Laboratory Features in Drug-Induced Lupus Compared with Idiopathic SLEa
| Feature | Anti-TNF-Related Lupus (%) | Procainamide-Related Lupus (%) | Idiopathic SLE (%) |
|---|---|---|---|
| ANA | 79 | >95 | 99 |
| Anti-dsDNA | 72 | <5 | 90 |
| Rash/cutaneous involvement | 67 | <5 | 54-70 |
| Arthritis | 31 | 20 | 83 |
| Fever/general symptoms | 23 | 45 | 42 |
| Hypocomplementemia | 17 | <5 | 48 |
| Leukopenia | 14 | 15 | 66 |
| Serositis | 12 | 50 | 28 |
| Anticardiolipin antibodies | 11 | 5-20 | 15 |
| Glomerulonephritis | 7 | <5 | 34 |
| Thrombocytopenia | 6 | <5 | 31 |
| Neuropsychiatric | 3 | <5 | 12 |
| Anti-histone antibodies | Not reported | >95 | 50-60 |
Abbreviations: ANA, antinuclear antibodies; dsDNA, double-stranded DNA; SLE, systemic lupus erythematosus; TNF, tumor necrosis factor.
a
Adapted from Ramos-Casals et al. [5].