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. 2012 Oct 11;287(48):40106–40118. doi: 10.1074/jbc.M112.380865

FIGURE 1.

FIGURE 1.

Trim28 levels increase in NSCLC tumors relative to normal tissue, but high Trim28 in early-stage tumors increases overall survival. A, data from (11) were examined. Results indicate that all three NSCLC tumor types have elevated Trim28 mRNA relative to adjacent normal tissue and that large cell carcinoma (LCC) has higher Trim28 than adenocarcinoma (ADC) and squamous cell carcinoma (SCC). p values are as follows: normal-ADC (p = 0.0003), normal-SCC (p < 0.0001), normal-LCC (p < 0.0001), ADC-LCC (p < 0.0001), SSC-LCC (p = 0.002), and ADC-SCC (p = 0.77). B, examination of microarray data from (18), which included a mixture of adenocarcinoma stages, reveals nonsignificant association between Trim28 mRNA expression with overall survival (p = 0.42). C, survival in Stage 1A tumors with high Trim28 is increased (p = 0.02). D, Trim28 protein levels were measured using AQUA in an early stage lung cancer TMA (see “Experimental Procedures”). Results show significant positive association between overall survival and Trim28 levels (p = 0.003).