FIGURE 4.
Effect of dietary selenium on plasma selenium biomarkers in Sepp1c/c/alb-cre+/− mice. A depicts plasma selenium biomarkers in Sepp1c/c/alb-cre+/− (n = 5) and Sepp1c/c (n = 4) mice that had been fed a diet supplemented with 0.25 mg of selenium/kg for 4 weeks beginning at weaning. B depicts plasma selenium biomarkers in mice fed diets supplemented with 0.25, 1, and 4 mg of selenium/kg. In that experiment, mice that had been fed 0.25 mg of selenium/kg diet for 1–2 months beginning at weaning were used for the study. One group (n = 4) continued to be fed the same diet, and two other groups (n = 5 in each group) were switched to the 1 and 4 mg/kg diets for 4 weeks before plasma was obtained. Values in both panels are means with 1 S.D. indicated by a bracket. Percentages in A indicate that values were significantly different (p < 0.05) by Student's t test. Asterisks in B indicate that values were different from the preceding value (p < 0.05) by Tukey's multiple comparison test.