FIGURE 8.
Effect of hepatocyte Sepp1 deletion on tissue and whole-body selenium concentrations in selenium-adequate (A) and selenium-deficient (B) mice. Selenium-adequate mice were fed a diet supplemented with 0.25 mg of selenium/kg for 4 weeks beginning at weaning. Selenium-deficient mice were fed a selenium-deficient diet for 12 weeks beginning at weaning. Values are means with the bracket indicating 1 S.D. (n = 3–4). Values in every pair were significantly different from each other (p < 0.05) by Student's t test. Percentages indicate the differences. Plasma biomarker values of the selenium-adequate animals (A) are shown in Fig. 4A. Plasma Sepp1 was not detectable (<0.5 mg/liter) in any of the four selenium-deficient Sepp1c/c/alb-cre+/− mice (B) and was 2.2 ± 0.1 mg/liter, n = 3, in the Sepp1c/c mice.