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. 2012 Oct 9;287(48):40513–40524. doi: 10.1074/jbc.M112.404541

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — Dusp4 is highly expressed in hearts of Lmna^H222P/H222P mice. A, qPCR analysis of Dusp1–Dusp12 mRNA in hearts of 16-week-old Lmna^H222P/H222P (Lmna^H222P) and WT (Lmna^WT) mice (n = 5). B, qPCR analysis of Dusp4 mRNA in various tissues from 16-week-old Lmna^H222P/H222P and WT mice (n = 3). C, qPCR analysis of Dusp4 mRNA in hearts from 8-week-old Lmna^H222P/H222P mice (n = 3), 6-week-old Lmna^−/− mice (n = 3), and 8-week-old PPARγ transgenic (Pparg Tg) mice (n = 4). WT denotes controls for the respective mouse models. D, qPCR analysis of Dusp4 mRNA (left panel) and Western blot (right panel) of phospho-ERK1/2 (pERK1/2), total ERK1/2 (ERK1/2), DUSP4, and α-tubulin in hearts of 4-week-old Lmna^H222P/H222P and WT mice (n = 3). The numbers above the blots denote individual samples. E, qPCR analysis of Nppa and Nppb mRNA in hearts of 4–16-week-old Lmna^H222P/H222P and WT mice (n = 3).