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. 2012 Oct 9;287(48):40513–40524. doi: 10.1074/jbc.M112.404541

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Cardiac-selective overexpression of Dusp4 impairs heart function. A, representative hearts (left panels) and heart weight to tibia length ratios (right panels) of 16-week-old Dusp4 Tg⁺ and Tg⁻ littermates. The hash marks above hearts correspond to millimeters. B, representative motion mode echocardiographic tracings (top panels) and graphic representations for left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), fractional shortening (FS), and ejection fraction (EF) of 16-week-old Dusp4 Tg⁺ mice and Tg⁻ littermates (n = 12 mice for Tg⁻ and n = 16 for Tg⁺). Each circle represents an individual mouse, and the horizontal bars denote means. C, qPCR analysis of Nppa, Nppb, Col1a1, Col1a2, and Fn1 mRNA expression in hearts of 16-week-old Dusp4 Tg⁺ and Tg⁻ littermates (n = 10 samples).