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Model showing the role of AKAP-Lbc in the regulation of Shp2 activity by PKA. AKAP-Lbc assembles a signaling complex composed of PKA and Shp2 in cardiac myocytes. Stress conditions (e.g. chronic activation of the β-adrenergic receptor) lead to PKA activation, thereby promoting inhibition of Shp2 activity, which may contribute to the induction of cardiac hypertrophy.
