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A summary of IRS1 molecular determinants required for CRL7-dependent degradation. The domain structure of human IRS-1 is shown. Both Ser-307/Ser-312 and Ser-527 S6K1 phosphorylation consensus sites are shown, each required for Fbw8-dependent degradation. Seven IRS1 fragments are characterized for Fbw8-dependent degradation, two of which were analyzed for ubiquitination by CRL7 in vitro.
