Table 1.
Recent preclinical studies of human tumours treated with miRNA.
| Cancer | microRNA | Delivery | Dispensing Route | Reference |
|---|---|---|---|---|
| Breast carcinoma | miR-10b | 2′-O-Me-modified | Tail vein | 54 |
| duplex miR-22 | RNA-jetPEI (polyethylenimine) | Local | 55 | |
| Non-small cell lung cancer | Pre-miR-34a | Lipid-based delivery vehicle | Local and systemic | 47 |
| Pre-miR-let7b | Lipid-based delivery vehicle | Local and systemic | 52,53 | |
| Lung cancer | Pre-miR-133b | cationic lipoplexes | Systemic | 56 |
| Colon carcinoma | miR-145 and miR-33a | Low molecular weight PEI/miRNA complexes | Local and systemic | 57 |
| Prostate tumor | Pre- miR-16 | Atelocollagen | Systemic | 58 |
| Hepatocarcinoma | miR-143 | hsa-miR-143 gene expressing vector | Intratumoral | 59 |