Fig. 3.

Gene expression in the developing neural crest. The sequence of expressed genes activated during development of the neural crest has largely been determined. Modulation of these genes utilizing conditional and regulable GEMM approaches will help to elucidate the specific role of each gene in fatespecification and commitment to lineage restricted (sympathetic and parasympathetic) derivatives. These genes are also ideal for targeting of NB specific initiator mutations to the appropriate tissue-compartment and precursor cell that may be required for induction of NB. TiC, tumor initiating cell, sNPC, sympathetic neuronal precursor cell, NPC, neuronal precursor cell, sN, sympathetic neuron.