Figure 1.

Vascular endothelial growth factor suppresses ascites-derived T-cell proliferation. (A) Time kinetics (0–14 days) of VEGF-induced (0.1–100 ng ml⁻¹) reduction of T-cell proliferation, as assessed via ³H-thymidine incorporation assay. Pooled data from three cancer patients are shown. (B) Dose-dependent (0.1–100 ng ml⁻¹) VEGF-induced inhibition of T-cell expansion. Cell growth was measured at day 14. Pooled data (n=15) are shown. Asterisks denote statistically significant differences (P<0.05) compared with control (*), 1 ng ml⁻¹ (**), 5 ng ml⁻¹ (***) and 10 ng ml⁻¹ (****).