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. 2012 Oct 18;107(11):1892–1900. doi: 10.1038/bjc.2012.475

Figure 3.

Figure 3

(A) Distribution of TMSB15A expression in luminal carcinomas and TNBC from GeparTrio. Dots indicate individual tumours. Red lines, medians. P, Mann–Whitney test. (B) Upper panel: determination of a cutoff point of TMSB15A gene expression for TNBC in GeparTrio. All possible cutoff points were considered and the corresponding odds ratios were calculated and plotted. Each data point in the line gives the corresponding OR and the 95% CI (dotted lines) on the y-axis. Vertical line: most significant split. Lower panel: waterfall plot for TNBC in GeparTrio charts each tumour as a vertical bar. Green bars represent cases with correct pCR classification, red bars represent cases with wrong pCR classification. Sensitivity and specificity of the cutoff point are indicated. (C) Pathological complete response (pCR) rates in dependence of TMSB15A status in TNBC from GeparTrio. For dichotomisation into a TMSB15A low and high expression group, the subtype-specific cutoff point was used (11.7 ΔCT). P-values were calculated by logistic regression. *Indicates significant values. The colour reproduction of this figure available at the British Journal of Cancer online.