Table 3. Clinico-pathological characteristics of luminal carcinomas and TNBC in GeparTrio and GeparQuattro.
| GeparTrio | GeparQuattro | |||||||
|---|---|---|---|---|---|---|---|---|
| Total n (%) | Luminal n (%) | Triple-negative n (%) | P | Total n (%) | Luminal n (%) | Triple-negative n (%) | P | |
| Total no. of samples | 212 | 151 | 61 | 383 | 249 | 134 | ||
| Age | ||||||||
| <50 years | 98 (46.2) | 65 (43.0) | 33 (54.1%) | 0.095a | 176 (46.0) | 108 (43.4) | 68 (50.7) | 0.123a |
| ⩽50 years | 114 (53.8) | 86 (57.0) | 28 (45.9%) | 207 (54.0) | 141 (56.6) | 66 (49.3) | ||
| Tumour histology | ||||||||
| Ductal | 184 (89.3) | 126 (86.3) | 58 (96.7) | 0.076b | 299 (78.1) | 180 (72.3) | 119 (88.8) | <0.0001b |
| Lobular | 17 (8.3) | 16 (11.0) | 1 (1.7) | 57 (14.9) | 53 (21.3) | 4 (3.0) | ||
| Other | 5 (2.4) | 4 (2.7) | 1 (1.7) | 27 (7.0) | 16 (6.4) | 11 (8.2) | ||
| Missing | 6 | 5 | 1 | |||||
| Tumour grade | ||||||||
| G1 | 21 (10.2) | 19 (13.1) | 2 (3.3) | <0.0001b | 9 (2.4) | 9 (3.8) | 0 (0) | <0.0001b |
| G2 | 139 (67.8) | 109 (75.2) | 30 (50.0) | 239 (64.1) | 188 (78.8) | 51 (38.1) | ||
| G3 | 45 (22.0) | 17 (11.7) | 28 (46.7) | 125 (33.5) | 42 (17.6) | 83 (61.9) | ||
| Missing | 7 | 6 | 1 | 10 | 10 | |||
| cT | ||||||||
| cT1 | 1 (0.5) | 0 (0) | 1 (1.7) | 0.246b | 5 (1.3) | 1 (0.4) | 4 (1.3) | 0.051b |
| cT2 | 138 (69.0) | 99 (70.2) | 39 (66.1) | 259 (67.6) | 163 (65.5) | 96 (71.6) | ||
| cT3 | 38 (19.0) | 24 (17.0) | 14 (23.7) | 59 (15.4) | 40 (16.1) | 19 (14.2) | ||
| cT4 | 23 (11.5) | 18 (12.8) | 5 (8.5) | 60 (15.7) | 45 (18.1) | 15 (11.2) | ||
| Missing | 12 | 10 | 2 | 10 | ||||
| cN | ||||||||
| cN0 | 102 (50.2) | 76 (53.5) | 26 (42.6) | 0.120a | 187 (48.8) | 115 (46.2) | 72 (53.7) | 0.096a |
| cN1–3 | 101 (49.8) | 66 (45.5) | 35 (57.4) | 196 (51.2) | 134 (53.8) | 62 (46.3) | ||
| Missing | 9 | 9 | ||||||
| pCR | ||||||||
| pCR | 32 (15.1) | 11 (7.3) | 21 (34.4) | <0.0001a | 60 (15.7) | 20 (8.0) | 40 (29.9) | <0.0001a |
| No pCR | 180 (84.9) | 140 (92.7) | 40 (65.6) | 323 (84.3) | 229 (92.0) | 94 (70.1) | ||
Abbreviations: cN=clinical node stage; cT=clinical tumour stage; pCR=pathological complete response; TNBC=triple-negative breast cancer.
a
Fisheŕs exact test.
b
Pearsońs chi-square test.