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Normalized mRNA levels in tumor cells isolated by laser microdissection from melanoma patients. The progressing metastases (P) obtained from both patients showed low residual levels of HLA-A, -B and -C loci. In contrast, the regressing tumor cells (R) displayed a high transcription of the tree HLA loci. Regressing metastases obtained after M-VAX treatment in patient M2 showed higher HLA loci expression than those obtained after interferon α 2b.
