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. 2012 Nov 23;2:145. doi: 10.3389/fcimb.2012.00145

Figure 1.

Figure 1

A schematic model for TLRs activation by diverse mycobacterial antigens. TLRs are involved in the innate recognition and responses in innate immune cells to numerous mycobacterial antigens. Some mycobacterial antigens including LpqH, lipoarabinomannan (LAM), lipomannan (LM), 38-kDa antigen, LprG, LprA, PhoS1, trehalose dimycolate (TDM), phosphatidylinositol mannoside (PIM) activate TLR2/1 or 6, whereas TLR4 recognizes heat shock protein (HSP) 60/65 and 38-kDa antigen. TLR activation by mycobacterial antigens leads an intracellular signaling pathway that culminates in the production of proinflammatory in macrophages and dendritic cells through MAPK and NF-κB pathways.