Figure 5.
Molecular mechanism of PF-PC synapse formation. Before PF-PC synapse formation, Cbln1 secreted from cerebellar GCs may interact with presynaptic NRXNs. Cbln1-induced NRXN dimerization is not sufficient to trigger presynaptic differentiation. When the contact between the PF terminal and PC spine takes place, GluRδ2 triggers synapse formation by clustering four NRXNs through triad formation.