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. Author manuscript; available in PMC: 2012 Nov 23.
Published in final edited form as: Nat Neurosci. 2008 Nov 23;12(1):21–23. doi: 10.1038/nn.2230

Figure 1.

Figure 1

Unitary fields generated by basket cells are hyperpolarizing. (a) Left, light micrograph of a hippocampal slice with a simultaneous whole-cell (WC) and field recording (3 M NaCl) of a basket cell. SLM, stratum lacunosum moleculare; SO, stratum oriens; SP, stratum pyramidale; SR, stratum radiatum. Middle, reconstruction of the biocytin-filled basket cell. Dendrites are shown in black and axons are in gray. Right, uField (top, black trace) recorded in stratum pyramidale in response to the action potential (bottom) in the basket cell and abolished by gabazine (2.5 μM, gray trace). (b) Summary (left) and representative example (right) of uFields evoked by basket cells and recorded extracellularly in multiple layers (n = 9). The pyramidal cell (copied from ref. 15) illustrates the location of the recording electrode along the somato-dendritic axis. (c) Left, the uField evoked by a basket cell in control conditions (black) or with CPA (1 μM, light gray) or CPA + DPCPX (10 μM, dark gray). Right, summary of the effects of CPA on the uField IPSPs (n = 10) and whole-cell uIPSCs (n = 3) from basket cells. Data shown are mean ± s.e.m.